منابع مشابه
TLRs, Alcohol, HCV, and Tumorigenesis
Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endo...
متن کاملAlcohol, HCV, and HIV: The Perfect Storm
OPEN ACCESS The World Health Organization (WHO) recently estimated that approximately 2.3 million individuals worldwide are coinfected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) [1]. HIV-infected individuals were, on average, 6 times more likely than HIV-negative individuals to be infected with HCV [1]. In Russia, there were approximately 980,000 people living with HIV,...
متن کاملTLRs and chronic inflammation.
After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the homeostasis of commensal flora and in the r...
متن کاملTLRs and innate immunity.
One of the most fundamental questions in immunology pertains to the recognition of non-self, which for the most part means microbes. How do we initially realize that we have been inoculated with microbes, and how is the immune response ignited? Genetic studies have made important inroads into this question during the past decade, and we now know that in mammals, a relatively small number of rec...
متن کاملTLRs as miRNA receptors.
MicroRNAs (miRNA) are small noncoding RNAs with gene regulatory functions. Their expression is frequently dysregulated in almost all human tumors and they can be found circulating within exosomes secreted by cancer cells. In addition to being promising cancer biomarkers with diagnostic, prognostic, and theranostic implications, circulating miRNAs have also important biologic functions: they can...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology Research and Practice
سال: 2010
ISSN: 1687-6121,1687-630X
DOI: 10.1155/2010/518674